PIVAGABINE - A NOVEL PSYCHOACTIVE DRUG

Pivagabine (4-[(2.2-dimethyl-1-oxopropyl)amino]butanoic acid, CAS 6954 2-93-4, Tonerg(R)) is a metabolically stable compound with a modulator y effect on some biochemical parameters involved in stress conditions (corticotropin releasing factor, neurosteroids). The compound, tested in several animal models, prevents stress-correlated behavioural defic its. Moreover. pivagabine has a highly significant therapeutic potenti al in clinical conditions characterized by manifestations of psycholog ical distress due to an inadequate management of stressful events.