PLASMA-CELL GRANULOMA OF THE ORAL CAVITY - A REPORT OF 2 CASES AND REVIEW OF THE LITERATURE

We report two rare cases of plasma cell granuloma arising in the extra gingival oral cavity. These are tumorous proliferations composed predo minantly of reactive plasma cells, Both patients presented with solita ry mass lesions that were clinically suspicious for malignancy. One pa tient presented with a mass that grew slowly for 2 years and involved the lip; in the second patient, a mass developed in the buccal mucosa Histologically, both lesions were characterized by lobules of plasma c ells separated by thick collagenous bands. A variable number of admire d lymphocytes and histiocytes was noted in both cases, In situ hybridi zation and immunostaining for kappa and lambda light chains revealed a polyclonal plasma cell population, In situ hybridization for Epstein- Barr virus failed to demonstrate evidence of viral expression in eithe r case. Both patients are free of disease after 8-month and 12-month f ollow-ups, Although plasma cell granuloma in the oral cavity is rare, it is important to recognize this entity as a benign inflammatory lesi on.