AN IMPROVED SYNTHESIS OF 2-CHLORINATED IMIDAZO[1,2-ALPHA]PYRIDINES AND THE APPLICATION OF THIS PROCEDURE FOR THE SYNTHESIS OF SEVERAL NEW POLYCHLORINATED IMIDAZO[1,2-ALPHA]PYRIDINES

Authors
GUDMUNDSSON KS DRACH JC TOWNSEND LB
Citation
Ks. Gudmundsson et al., AN IMPROVED SYNTHESIS OF 2-CHLORINATED IMIDAZO[1,2-ALPHA]PYRIDINES AND THE APPLICATION OF THIS PROCEDURE FOR THE SYNTHESIS OF SEVERAL NEW POLYCHLORINATED IMIDAZO[1,2-ALPHA]PYRIDINES, Synthetic communications, 27(10), 1997, pp. 1763-1775
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
10
Year of publication
1997
Pages
1763 - 1775
Database
ISI
SICI code
0039-7911(1997)27:10<1763:AISO2I>2.0.ZU;2-9
Abstract
Polychlorinated imidazo[1,2-a]pyridines were synthesized as analogs of certain chlorinated benzimidazoles. The imidazo[1,2-a]pyridines were obtained by a condensation of ethyl bromoacetate and chlorinated 2-ami nopyridines. These condensation products were treated with an ion exch ange resin to effect an exchange of hydrobromide salts with hydrochlor ide salts. These compounds were subsequently treated with POCl3 to con vert the imidazo[1,2-a]pyridin-2-ones into 2-chloroimidazo[1,2-a]pyrid ines.