THIOBARBITURIC ACID REACTIVE SUBSTANCES ARE INCREASED IN THE SUBCUTANEOUS FAT TISSUE OF PATIENTS WITH END-STAGE RENAL-DISEASE

Background, Patients with end-stage renal disease are thought to be in a highly peroxidative state, based on studies showing decreased serum antioxidant activity and increased peroxidative products. In this stu dy we confirm these findings by examining lipid peroxidation in subcut aneous fat tissue in uraemia. Subjects and methods, Twenty-seven subcu taneous fat samples were taken from patients with end-stage renal dise ase when they underwent intervention for arteriovenous fistula for hae modialyis or for catheter insertion for continuous ambulatory peritone al dialysis. The control samples were taken from 11 patients with norm al renal function and without any history of renal disease who had sur gical interventions. Lipid peroxides were measured as thiobarbituric a cid reactive substance. Results. The concentration of thiobarbituric a cid reactive substances in subcutaneous fat tissue in the patients wit h end-stage renal disease is 1.223 +/- 0.636 nmol/mg fat tissue (mean +/- SD) whereas the level in the control group is 0.097 +/- 0.054 nmol /mg fat tissue. A comparison of the two groups by Student's t test rev ealed a highly significant difference (P<0.001). Conclusions, This stu dy supports the finding of a severe peroxidative state in patients wit h end-stage renal disease.