STABILITY OF ONDANSETRON AND FLUCONAZOLE IN 5-PERCENT DEXTROSE INJECTION AND NORMAL SALINE DURING Y-SITE ADMINISTRATION

The stability of ondansetron and fluconazole in 5% dextrose injection and normal saline during simulated Y-site injection at room temperatur e was studied. Ondansetron 0.03, 0.1 and 0.3 mg/ml were admired 1:1 wi th fluconazole 2 mg/ml. The solutions were stored at room temperature and samples were retrieved at time 0, 1, 2, 4 and 12 hr for immediate assay. At the time of the assay and before any dilution, each sample w as visually inspected for clarity, color, precipitation, and the pH wa s determined. Drug concentrations were measured by a stability-indicat ing high performance liquid chromatograph. Ondansetron 0.03, 0.1 and 0 .3 mg/ml were stable when mixed with concentration of fluconazole 2 mg /ml. There were no change in clarity and color and no precipitates in any admixture for 12 hr of inspection. The pH measurements did not hav e a particular trend in any direction over time.