CYTOTOXIC CONSTITUENTS OF PILEA-MONGOLICA

Bioassay-guided fractionation of the aerial parts of Pilea mongolica ( Urticaceae) afforded two cytotoxic triterpenoids, epi-oleanolic acid ( I) and oxo-oleanolic acid (II). The structures of the compounds were c onfirmed by spectral and synthetic evidences. Compound I and compound II exhibited cytotoxicity against cultured human tumor cell lines, A54 9 (non small cell lung adenocarcinoma), SK-OV-3 (ovarian), SK-MEL-2 (s kin melanoma), XF498 (CNS) and HCT15 (colon) with ED50 values of 3.2 s imilar to 8.1 mu g/ml and 0.7 similar to 6.8 mu g/ml, respectively.