The assessment of patient quality of life is assuming increasing impor
tance in medicine and healthcare. In addition to their biological effe
cts, illnesses, diseases and their treatments can have significant imp
act on mobility, mood, life satisfaction, cognition and the ability to
fulfil occupational, social and family roles. The emerging quality of
life construct may be viewed as a paradigm shift in outcome measureme
nt since it shifts the focus of attention from symptoms to functioning
. This holistic approach more clearly establishes the patient as the c
entre of attention and subsumes many of the traditional measures of ou
tcome. This paper introduces the concept of quality of life and descri
bes the significant difficulties in definition, measurement and interp
retation that must be addressed before such measures can be used as re
liable and valid indicators of disease impact and treatment outcomes.
It is argued that the unique individual perspective of the patient on
his or her own quality of life must be incorporated into outcome asses
sments aimed at improving the quality of healthcare delivery in chroni
c diseases and in terminal conditions.