PROTEIN FOLDS FROM PAIR INTERACTIONS - A BLIND TEST IN FOLD RECOGNITION

We submitted nine predictions to CASP2 using our fold recognition prog ram ProFIT. Two of these structures were still unsolved by the end of the experiment, six had a recognizable fold, and one fold was new, Fou r predictions of the six recognizable folds were correct, Two models w ere excellent in terms of alignment quality (T0031, T0004): in one the alignment was partially correct (T0014), and one fold was correctly i dentified (T0038), We discuss improvements of the program and analyze the prediction results. (C) 1998 Wiley-Liss, Inc.