BPC 157S EFFECT ON HEALING

The 15 amino acid agent BPC 157, showing a wide range of organoprotect ive action in different experimental models, was used in our experimen ts in order to establish its influence on different elements connected with the healing process. Elements thought to be of greatest importan ce in the process of healing are formation of granulation tissue, angi ogenesis and production of collagen. In our work we tested the influen ce of BPC 157 on: granulation tissue and collagen formation, on angiog enesis as well as on tensile strength development, using three experim ental rat models: 1) skin incisional wounds; 2) colon-colon anastomose s; and 3) angiogenesis model with synthetic sponge implantation. The s pecimens were histologically assessed for collagen, reticulin and bloo d vessels using scoring and morphometry. In all experiments significan t differences between BPC 157-treated animals and controls were found, showing a strong, promoting involvement of BPC in the healing process . It is worth noting that these effects were achieved by different rou tes of application, including intragastric and local, making BPC 157 a potentially useful therapeutic agent.