LOCALIZATION OF THE MGLU4A METABOTROPIC GLUTAMATE-RECEPTOR IN RAT CEREBELLAR CORTEX

Authors
MATEOS JM AZKUE J SARRIA R KUHN R GRANDES P KNOPFEL T
Citation
Jm. Mateos et al., LOCALIZATION OF THE MGLU4A METABOTROPIC GLUTAMATE-RECEPTOR IN RAT CEREBELLAR CORTEX, HISTOCHEM C, 109(2), 1998, pp. 135-139
Citations number
20
Categorie Soggetti
Cell Biology
Journal title
HISTOCHEMISTRY AND CELL BIOLOGY
ISSN journal
09486143 → ACNP
Volume
109
Issue
2
Year of publication
1998
Pages
135 - 139
Database
ISI
SICI code
0948-6143(1998)109:2<135:LOTMMG>2.0.ZU;2-H
Abstract
The subcellular localization of the mGlu4a metabotropic glutamate rece ptor was investigated in rat cerebellum. At the light microscopical le vel, strong mGlu4a immunoreactivity was found in the molecular layer. A post-embedding immunogold method for electron microscopy revealed go ld particles at the presynaptic sites of synapses made by parallel fib er terminals with dendritic spines of Purkinje cells. These observatio ns support electrophysiological evidence indicating an autoreceptor fu nction of mGlu4 receptors at these synapses.