ANTIPLASMODIAL ACTIVITY OF MONOMERIC AND DIMERIC CARBAZOLES

Authors
BRINGMANN G LEDERMANN A HOLENZ J KAO MT BUSSE U WU HG FRANCOIS G
Citation
G. Bringmann et al., ANTIPLASMODIAL ACTIVITY OF MONOMERIC AND DIMERIC CARBAZOLES, Planta medica, 64(1), 1998, pp. 54-57
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences","Chemistry Medicinal
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
64
Issue
1
Year of publication
1998
Pages
54 - 57
Database
ISI
SICI code
0032-0943(1998)64:1<54:AAOMAD>2.0.ZU;2-5
Abstract
A series of mono-and dimeric natural and structurally modified carbazo les has been tested for activity against Plasmodium falciparum. One of the monomers, the synthetic compound 1,4-diacetoxy-3-methylcarbazole (17), displays the highest activity, with an IC50 value of 1.79 mu g/m l. It is distinctly more active than the as yet best natural compound, 1-hydroxy-3-methylcarbazole (4) (4).