ANTIMALARIAL XANTHONES FROM GARCINIA-COWA

Authors
LIKHITWITAYAWUID K PHADUNGCHAROEN T KRUNGKRAI J
Citation
K. Likhitwitayawuid et al., ANTIMALARIAL XANTHONES FROM GARCINIA-COWA, Planta medica, 64(1), 1998, pp. 70-72
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences","Chemistry Medicinal
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
64
Issue
1
Year of publication
1998
Pages
70 - 72
Database
ISI
SICI code
0032-0943(1998)64:1<70:AXFG>2.0.ZU;2-A
Abstract
Five xanthones from the bark of Garcinia cowa, namely 7-O-methylgarcin one E (1), cowanin (2), cowanol (3), cowaxanthone (4), and beta-mangos tin (5), were found to possess in vitro antimalarial activity against Plasmodium falciparum with IC50 values ranging from 1.50 to 3.00 mu g/ ml. Complete H-1- and C-13-NMR assignments of these compounds are also reported.