SESQUITERPENES, LIMONOID AND COUMARIN FROM THE WOOD BARK OF GUAREA-GUIDONIA

Investigation of the wood bark of Guarea guidonia (Meliaceae) led to t he isolation of a limonoid (mombasol), a coumarin (scopoletin), and si x sesquiterpenes [trans-1(10)-epoxy-4(15)-caryophyllene, 1(10)-epoxy-4 ,7-humuladiene, viridiflorol, 1(10),4-diepoxy-7-humulene, 3-oxo-10-all oaromadendranol, 1 beta-6 alpha-dihydroxyeudesm-4(15)ene]. The occurre nce of these metabolites in the Guarea genus is reported for the first time, Stigmasterol, sitosterol and its oleate and palmitate esters we re also obtained. Some corrections to the previously reported chemical shift assignments of 3-oxo-10-alloaromadendranol (C-13-NMR) were made .