OVERCOMING APOPTOSIS - NEW METHODS FOR IMPROVING PROTEIN-EXPRESSION SYSTEMS

Cellular suicide, or apoptosis, is responsible for a significant propo rtion of cell death in many bioprocesses, With the progressive elucida tion of the biochemical and genetic events leading to this form of cel l death, it is now possible to implement strategies for extending the productive lifetimes of cells in culture, These strategies may include nutritional, genetic and chemical methods that enhance cell survival and performance during the critical stages of a culture process, leadi ng to improvements in the production capacity for valuable biotechnolo gical products.