The three isomeric guanylic acids (5'-GMP, 3'-GMP and 2'-GMP) and the
3':5'-cyclic derivative (cGMP) form, in water solution, left-handed co
lumnar aggregates which, at higher concentration, pack to give left-ha
nded cholesteric mesophases. The self-assembly process and liquid crys
tal formation are discussed in relation to the behaviour of the 2'-deo
xy analogues.