SCREENING OF LARVAL PUPAL P-ELEMENT INDUCED LETHALS ON THE 2ND-CHROMOSOME IN DROSOPHILA-MELANOGASTER - CLONAL ANALYSIS AND MORPHOLOGY OF IMAGINAL DISCS/

We have carried out screens for lethal mutations on the second chromos ome of Drosophila melanogaster that are associated with abnormal imagi nal disc morphologies, particularly in the wing disc. From a collectio n of 164 P element-induced mutations with a late larva/pupa lethal pha se we have identified 56 new loci whose gene products are required for normal wing disc development and for normal morphology of other larva l organs. Genetic mosaics of these 56 mutant lines show clonal mutant phenotypes for 23 cell-viable mutations. These phenotypes result from altered cell parameters. Causal relationships between disc and clonal phenotypes are discussed.