VASCULITIC BASILAR ARTERY THROMBOSIS IN CHRONIC CANDIDA-ALBICANS MENINGITIS

Background: Cerebrovascular complications of meningitis have been most extensively documented in the setting of acute bacterial or chronic t uberculous meningitis. Involvement of major cerebral vessels is rare a nd basilar artery thrombosis has not been reported in fungal meningiti s secondary to candida infection. Methods: We describe the clinical co urse and neuropathological findings in a woman with chronic meningitis due to Candida albicans, Results: The diagnosis remained elusive ante mortem despite analysis of 7 large volume CSF samples and examination of a meningeal and cortical biopsy. Death followed extensive brainstem and temporo-occipital infarction secondary to basilar artery thrombos is, The basilar artery occlusion was secondary to an intense, granulom atous and necrotizing basal meningitis focally extending to the media and intima, Conclusions: This paroxysmal and devastating complication of untreated chronic candida meningitis reinforces that a trial of emp irical therapy with both antituberculous and antifungal agents should be considered in most cages of chronic culture-negative lymphocytic me ningitis.