CYTOSKELETAL PROTEINS AND GOLGI DYNAMICS

Association of the Golgi complex with cytoskeletal elements, in partic ular microtubules, is required for maintenance of the Golgi's characte ristic spatial location within cells and for efficient delivery of pro teins and lipids to diverse cellular sites. Recent work has suggested the mechanisms underlying this association involve components, such as ankyrin and spectrin, that facilitate Golgi membrane association with motor proteins, including cytoplasmic dynein, kinesin and myosin. Und erstanding how these associations are regulated and what roles they pl ay in Golgi trafficking and dynamics is fundamental for insight into t he spatial and functional integration of secretory membrane traffic.