ENANTIOSELECTIVE SYNTHESIS OF (S)-CALYCOTOMINE EMPLOYING CATALYTIC ASYMMETRIC HYDROGENATION WITH AN IRIDIUM(I)-(R)-BINAP-PHTHALIMIDE COMPLEX

Authors
MORIMOTO T SUZUKI N ACHIWA K
Citation
T. Morimoto et al., ENANTIOSELECTIVE SYNTHESIS OF (S)-CALYCOTOMINE EMPLOYING CATALYTIC ASYMMETRIC HYDROGENATION WITH AN IRIDIUM(I)-(R)-BINAP-PHTHALIMIDE COMPLEX, Tetrahedron : asymmetry, 9(2), 1998, pp. 183-187
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
2
Year of publication
1998
Pages
183 - 187
Database
ISI
SICI code
0957-4166(1998)9:2<183:ESO(EC>2.0.ZU;2-9
Abstract
An optically active l-hydroxymethyl-substituted tetrahydroisoquinoline alkaloid, (S)-calycotomine 1, was conveniently synthesized by using c atalytic asymmetric hydrogenation of zyloxymethyl-3,4-dihydro-6,7-dime thoxyisoquinoline 6 with 0.5 mol % of an iridium(I) complex of (R)-BIN AP in the presence of 3,4,5,6-tetrafluorophthalimide. (C) 1998 Elsevie r Science Ltd. All rights reserved.