SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF ENANTIOPURE (2R,5R)-(-2,5-DIMETHYLTHIOLANE())

Authors
OTTEN S FROHLICH R HAUFE G
Citation
S. Otten et al., SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF ENANTIOPURE (2R,5R)-(-2,5-DIMETHYLTHIOLANE()), Tetrahedron : asymmetry, 9(2), 1998, pp. 189-191
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
2
Year of publication
1998
Pages
189 - 191
Database
ISI
SICI code
0957-4166(1998)9:2<189:SASCOE>2.0.ZU;2-L
Abstract
Enantiopure (2R,5R)-(+)-2,5-dimethylthiolane was synthesized by cycliz ation with sodium sulfide of the dimesylate of (2S,5S)-(+)-2,5-hexaned iol, which was obtained by baker's yeast (Saccharomyces cerevisiae) re duction of acetonyl acetone in high enantiomeric purity. The structure of the diol and absolute stereochemistry of the sulfone derived from the title molecule were determined by X-ray crystal structure analysis . (C) 1998 Elsevier Science Ltd. All rights reserved.