S. Otten et al., SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF ENANTIOPURE (2R,5R)-(-2,5-DIMETHYLTHIOLANE()), Tetrahedron : asymmetry, 9(2), 1998, pp. 189-191
Enantiopure (2R,5R)-(+)-2,5-dimethylthiolane was synthesized by cycliz
ation with sodium sulfide of the dimesylate of (2S,5S)-(+)-2,5-hexaned
iol, which was obtained by baker's yeast (Saccharomyces cerevisiae) re
duction of acetonyl acetone in high enantiomeric purity. The structure
of the diol and absolute stereochemistry of the sulfone derived from
the title molecule were determined by X-ray crystal structure analysis
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