SYNTHESIS AND APPLICATION IN ENANTIOSELECTIVE HYDROGENATION OF NEW FREE AND CHROMIUM COMPLEXED AMINOPHOSPHINE-PHOSPHINITE LIGANDS

Authors
PASQUIER C NAILI S PELINSKI L BROCARD J MORTREUX A AGBOSSOU F
Citation
C. Pasquier et al., SYNTHESIS AND APPLICATION IN ENANTIOSELECTIVE HYDROGENATION OF NEW FREE AND CHROMIUM COMPLEXED AMINOPHOSPHINE-PHOSPHINITE LIGANDS, Tetrahedron : asymmetry, 9(2), 1998, pp. 193-196
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
2
Year of publication
1998
Pages
193 - 196
Database
ISI
SICI code
0957-4166(1998)9:2<193:SAAIEH>2.0.ZU;2-P
Abstract
A straightforward synthesis of new free and Cr(CO)(3) complexed AMPP l igands (4-7) is described starting from (S)-indoline-2-carboxylic acid . The ligands were applied successfully in the asymmetric hydrogenatio n of ex-functionalized ketones i.e. a ketolactone 8, a ketoamide 9 and an aminoketone 10 leading to the corresponding optically active alcoh ols in 99, 97, and 99% ee respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.