The efficacy of a new inactivated vaccine against Babesia divergens wa
s evaluated by means of inoculation tests. The infection was initiated
by i.v. injection of blood containing 2 x 10(9) living parasites into
splenectomized and non-splenectomized calves. Clinical status and hem
atological parameters were determined. Serology examinations for antib
odies against B. divergens were carried out by indirect fluorescent an
tibody test (IFAT). Non-vaccinated and splenectomized animals exhibite
d experimental infections. In vaccinated and splenectomized animals, c
linical symptoms and prolonged incubation periods were observed.