THE HISTIDIN-RICH GLYCOPROTEIN PRO(186) SER POLYMORPHISM IS NOT RELATED TO MYOCARDIAL-INFARCTION IN THE ECTIM STUDY/

Authors
HERRMANN SM POIRIER O NICAUD V RUIDAVETS JB EVANS A ARVEILER D LUC G BARA L CAMBIEN F
Citation
Sm. Herrmann et al., THE HISTIDIN-RICH GLYCOPROTEIN PRO(186) SER POLYMORPHISM IS NOT RELATED TO MYOCARDIAL-INFARCTION IN THE ECTIM STUDY/, Thrombosis and haemostasis, 79(2), 1998, pp. 359-361
Citations number
18
Categorie Soggetti
Hematology,"Peripheal Vascular Diseas
Journal title
Thrombosis and haemostasis → ACNP
ISSN journal
03406245
Volume
79
Issue
2
Year of publication
1998
Pages
359 - 361
Database
ISI
SICI code
0340-6245(1998)79:2<359:THGPSP>2.0.ZU;2-S
Abstract
The histidin-rich glycoprotein (HRG) may contribute to coronary heart disease as a consequence of its possible thrombophilic properties. To test this hypothesis we have investigated the Pro(186)/Ser polymorphis m of the HRG gene, which is known to strongly affect plasma HRG levels , in a large multicenter case-control study of myocardial infarction ( MI). The results failed to demonstrate any association between the pol ymorphism and MI or angiographically assessed coronary stenosis.