FIRST STRUCTURALLY DEFINED CATALYST FOR THE ASYMMETRIC ADDITION OF TRIMETHYLSILYL CYANIDE TO BENZALDEHYDE

Authors
TARAROV VI HIBBS DE HURSTHOUSE MB IKONNIKOV NS MALIK KMA NORTH M ORIZU C BELOKON YN
Citation
Vi. Tararov et al., FIRST STRUCTURALLY DEFINED CATALYST FOR THE ASYMMETRIC ADDITION OF TRIMETHYLSILYL CYANIDE TO BENZALDEHYDE, Chemical communications, (3), 1998, pp. 387-388
Citations number
23
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
3
Year of publication
1998
Pages
387 - 388
Database
ISI
SICI code
1359-7345(1998):3<387:FSDCFT>2.0.ZU;2-4
Abstract
Titanium complex TiCl2L [H2L = s(3,5-ditert-butylsalicylidene)hexane-1 ,2-diamine] 2 has been prepared, characterised by X-ray crystallograph y and shown to be an active catalyst for the asymmetric addition of Me 3SiCN to benzaldehyde, producing ((S)-2-phenyl-2-trimethylsilyloxyacet onitrile in 86% ee at room temperature.