HIGHLY EFFICIENT SYNTHESIS OF PHOSPHORODITHIOATES DERIVED FROM 3'-THIOTHYMIDINE BY ANHYDRO-RING OPENING OF 2,3'-ANHYDRO-5'-O-TRITYLTHYMIDINE WITH O,O-DISUBSTITUTED PHOSPHORODITHIOIC ACIDS
W. Dabkowski et al., HIGHLY EFFICIENT SYNTHESIS OF PHOSPHORODITHIOATES DERIVED FROM 3'-THIOTHYMIDINE BY ANHYDRO-RING OPENING OF 2,3'-ANHYDRO-5'-O-TRITYLTHYMIDINE WITH O,O-DISUBSTITUTED PHOSPHORODITHIOIC ACIDS, Chemical communications, (3), 1998, pp. 427-428
Thymidine 3'-S-phosphorodithioate 4 and dithymidine-3'-S-phosphorodith
ioate 7 derived from 3'-thiothymidine are synthesized in excellent yie
ld under mild conditions by the nucleophilic ring opening of 2,3'-anhy
drothymidine with phosphorodithioic acids.