I. Felemovicius et al., RADIOPROTECTION OF THE RAT INTESTINAL-MUCOSA BY TIRILAZAD, International journal of radiation biology, 73(2), 1998, pp. 219-223
Citations number
18
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging","Biology Miscellaneous
Purpose: To assess intestinal radioprotection by systemic or lumenal t
irilazad mesylate and to test potential tumour radioprotection. Materi
als and methods: Segments of the mid small bowel were surgically exter
iorized. Tirilazad was given either intravenously or intralumenally 30
min prior to 11 Gy of X-irradiation to the exteriorized intestine. Ti
ssues were harvested 5 days later to measure crypts per circumference
and mucosal height. Potential tumour protection was assessed in a mous
e sarcoma model. Tumours implanted in the hind limb were allowed to gr
ow until a standard volume was attained, then irradiated (10 Gy) 30 mi
n after intravenous (i.v.) administration of saline or tirilazad. Tumo
ur growth was recorded for the next 22 days to determine if pretreatme
nt with tirilazad interfered with radiation effects. Results: Systemic
tirilazad provided no protection against intestinal damage and did no
t alter tumour growth after irradiation. Topical tirilazad yielded hig
hly significant protection of intestinal mucosa. Conclusions: These pr
eliminary observations showed that topical tirilazad diminished radiat
ion enteritis. Systemic drug had no effect on the severity of damage t
o the intestine nor did it inhibit radiation effects on a tumour.