Health and disease consist of amino acids and self image, cell membran
es and human ideals, muscles and politics. Only to a limited extent ca
n clinical practice be based on science. It can never be carried on in
isolation from political and cultural forces that influence patients'
health behaviour. Evidence-based medicine is essential but not suffic
ient. A continuous relationship with patients is a conditio sine qua M
on for general practice. The general practitioner must be a master of
pragmatic medicine. Rationality. the dominant modern trend may be dang
erous for patients and doctors: (1) advances in technology can give pa
tients and doctors the illusion of mastering the universe; (2) patient
s complain of being treated like bio-machines, without human touch. An
other symptom of modernity is the decline of religion. But patients an
d doctors are by no means rational beings. God, destiny and hope are r
eplaced by modern medico-scientific megalomania. Modern medicine is al
so strongly influenced by commercialization and invasion by bureaucrat
s. Instead of becoming a biomedical robot, the general practitioner mu
st learn to value the Aristotelian concept of phronesis. It means prac
tical wisdom and can only be gained by personal experience; a form of
learning by doing. Good clinical practice cannot come from science alo
ne, or from personal experience alone. It is an amalgam of scientia an
d phronesis.