GALENIC AND DERMOPHARMACEUTICAL EFFECTIVENESS STUDY OF AN EMULSIFIED PHARMACEUTICAL FORM WITH RETINOIC ACID

Retinoic acid constitutes an active that is already being used extensi vely in the fight against cutaneous aging. After a period in which cer tain scientific publications questioned its use, today there is no dou bt that retinoic acid continues to be an active with wide possibilitie s of use when it is formulated and administered correctly. In this wor k we propose a new formulation that, on the basis of a modem self-emul sifying excipient, incorporates retinoic acid in its composition. The work protocol is structured in the following points of study. Rheologi cal assay: Shear rate, shear stress, viscosity, thixotropy, rheodestru ction, and extensibility measurements were carried out. Other pharmaco technical assays: External appearance, interposition type, and pH cont rol were studied. Dermopharmaceutical effectiveness study: Biophysical non-invasive techniques were applied, according to a standardized wor k method. The following considerations can be made from the results: t he layout of the rheograms could fit, in principle, inside a non-Newto nian-shear-thinning flow behavior, with similar rheodestruction profil es. The hysteresis values, as well as the extensibility indexes that w ere obtained, determined a good degree of applicability. From the whol e of results, we could conclude that the formulation proposed is profi led like an emulsified pharmaceutical form with an excellent cosmetolo gical adaptation, eudermic pH, and soft emollient action, which prohib its the loss of superficial water that maintains the retinoic acid act ion.