The World Health Organization (WHO) estimates that human tuberculosis
(TB) incidence and deaths for 1990 to 1999 will be 88 million and 30 m
illion, respectively, with most cases in developing countries. Zoonoti
c TB (caused by Mycobacterium bovis) is present in animals in most dev
eloping countries where surveillance and control activities are often
inadequate or unavailable; therefore, many epidemiologic and public he
alth aspects of infection remain largely unknown. We review available
information on zoonotic TB in developing countries, analyze risk facto
rs that may play a role in the disease, review recent WHO activities,
and recommend actions to assess the magnitude of the problem and contr
ol the disease in humans and animals.