STEREOSELECTIVE SYNTHESIS AND BETA-BLOCKING ACTIVITY OF SUBSTITUTED DROXYPROPYL)OXIMINO]-2,3-DIHYDRO-1,8-NAPHTHYRIDINE AND DROXYPROPYL)OXIMINO]-2,3-DIHYDRO-1,8-NAPHTHYRIDINE - POTENTIAL ANTIHYPERTENSIVE AGENTS- PART VI

The synthesis of R-(+)- and S-(-)-isomers of substituted (E)- and oxyp ropyl)-oximino]-2,3-dihydro-1,8-naphthyridine, in enantiomeric pure fo rm, is described. These compounds showed an interesting beta-blocking activity. Generally, the (S)-enantiomers possess a slighthly higher af finity for beta receptors than the (R)-enantiomers.