ALIPHATIC ETHERS OF 1-(2,4-DICHLOROPHENYL)-2-(1-H-IMIDAZOLYL)ETHANOL - INFLUENCE OF RAMIFICATION AND OR UNSATURATION ON LIPOPHILICITY AND ANTIFUNGAL ACTIVITY/

Authors
TOURNAIREARELLANO C STIGLIANI JL RECOCHE C CAUJOLLE R PAYARD M LINAS MD SEGUELA JP
Citation
C. Tournairearellano et al., ALIPHATIC ETHERS OF 1-(2,4-DICHLOROPHENYL)-2-(1-H-IMIDAZOLYL)ETHANOL - INFLUENCE OF RAMIFICATION AND OR UNSATURATION ON LIPOPHILICITY AND ANTIFUNGAL ACTIVITY/, European journal of medicinal chemistry, 32(12), 1997, pp. 1001-1007
Citations number
30
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
32
Issue
12
Year of publication
1997
Pages
1001 - 1007
Database
ISI
SICI code
0223-5234(1997)32:12<1001:AEO1->2.0.ZU;2-X
Abstract
Ethers of 1-(2,4-dichlorophenyl)-2-(1-H-imidazolyl bearing ramified an d/or unsaturated chains have been synthesized in order to specify the role of lipophilicity or steric contributions on antifungal activity a gainst yeast for miconazole-like structures. The presence of ramificat ions on aliphatic chains (between 4 and 7 carbons) or unsaturation at the end, increases antifungal activity. For these compounds, lipophili city seems to be counterbalanced by steric contributions.