GASTRIC FUNCTION AFTER PYLORUS-PRESERVING DUODENECTOMY IN DOGS

Background/Aims: The purpose of this study was to delineate the altera tions in gastric physiology after pylorus-preserving duodenectomy (PPD ). Methodology: The duodenum was transected 2 cm distal to the pyloric ring in five dogs. A patch graft around the papilla. of Vater was pre served. Reconstruction was completed using an. end-to-end duodenojejun ostomy, anastomosis of the patch graft to the jejunum, and cholecystoj ejunostomy, in that order. Gastric acid analysis, serum gastrin. and s ecretin concentrations, and gastric emptying were investigated before and one and three months after surgery. Results: The postoperative mea n. basal and maximal acid outputs were not significantly increased. Fa sting serum gastrin concentrations remained unchanged. The fasting ser um secretin concentrations one month after surgery increased significa ntly as compared to the controls. There were no significant difference s in meal-stimulated gastrin or secretin responses or gastric emptying after surgery. Conclusions: The acid output and gut hormone release a fter PPD were maintained at preoperative Levels. Preservation of the d uodenal bulb is postulated to be responsible for the maintenance of ne ar-normal gastric physiology.