CELL AND MOLECULAR MECHANISMS OF PATHOGENESIS AND TREATMENT OF CANCER

Surgery remains the mainstay of treatment for most classes of human so lid tumours, with the principal exception of lymphomas, but it is insu fficient in many cases to guarantee cure. With few exceptions, recurre nt and metastatic solid tumours continue to defy attempts to develop e ffective adjuvant therapies. Recent insights into tumour biology revea l an increasingly complex picture of cell and molecular processes whic h confer heterogeneity and resistance to treatment upon tumours. These insights may also yield new targets for more effective adjuvant thera pies.