THE STIMULATION OF THE MITOCHONDRIAL PERMEABILITY TRANSITION BY DIHYDROLIPOATE AND ALPHA-LIPOATE

Authors
SARIS NEL KARJALAINEN A TEPLOVA VV LINDROS KO
Citation
Nel. Saris et al., THE STIMULATION OF THE MITOCHONDRIAL PERMEABILITY TRANSITION BY DIHYDROLIPOATE AND ALPHA-LIPOATE, Biochemistry and molecular biology international, 44(1), 1998, pp. 127-134
Citations number
37
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
44
Issue
1
Year of publication
1998
Pages
127 - 134
Database
ISI
SICI code
1039-9712(1998)44:1<127:TSOTMP>2.0.ZU;2-Q
Abstract
The effect of alpha-lipoate and dihydrolipoate on the mitochondrial pe rmeability transition was investigated. Both substances promoted the p ermeability transition in isolated rat liver mitochondria and in perme abilized hepatocytes, dihydrolipoate most potently in spite of it bein g a dithiol. The stimulation was prevented by Cyclosporin A or hydroxy butyltoluene but not by ascorbate. It is suggested that the greater po tency of dihydrolipoate could be due to formation of a radical.