ANGIOTENSIN-II AND RELATED PEPTIDES ALTER LIPOSOMAL MEMBRANE FLUIDITY

Citation
E. Brailoiu et al., ANGIOTENSIN-II AND RELATED PEPTIDES ALTER LIPOSOMAL MEMBRANE FLUIDITY, Biochemistry and molecular biology international, 44(1), 1998, pp. 203-209
Citations number
21
Categorie Soggetti
Biology
ISSN journal
10399712
Volume
44
Issue
1
Year of publication
1998
Pages
203 - 209
Database
ISI
SICI code
1039-9712(1998)44:1<203:AARPAL>2.0.ZU;2-U
Abstract
We investigated the effects of angiotensinogen (Ang), angiotensin I (A ng I), and angiotensin II (Ang II) on the fluidity of phosphatidylchol ine vesicles. Changes in fluidity were assessed by changes in anisotop y values calculated from fluorescence polarization measurements. All t hree compounds produced an increase in membrane fluidity when localize d inside the phosphatidylcholine vesicles. When placed outside the ves icles, Ang II increased bilayer rigidity (decreased fluidity), whereas Ang and Ang I produced no effect. These results suggest the possibili ty that these peptides may alter the fluidity of cell membranes by a d irect action on the phospholipid bilayer, which may in turn interfere with receptor-mediated effects.