A SHORT SYNTHESIS OF RIGID 2-ALKYLTHIO-2,2-DIARYL SUBSTITUTED ACETIC-ACIDS

Authors
GUALTIERI F MORDINI A PECCHI S SCAPECCHI S
Citation
F. Gualtieri et al., A SHORT SYNTHESIS OF RIGID 2-ALKYLTHIO-2,2-DIARYL SUBSTITUTED ACETIC-ACIDS, Tetrahedron, 54(10), 1998, pp. 2251-2256
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
10
Year of publication
1998
Pages
2251 - 2256
Database
ISI
SICI code
0040-4020(1998)54:10<2251:ASSOR2>2.0.ZU;2-5
Abstract
The metalation of rigid diphenyl methane derivatives has been studied, aiming at the synthesis of 2-alkylthio-2,2-diaryl substituted acetic acids esters, a class of compounds with a potential antimuscarinic act ivity. Mixed metal bases have shown to be necessary in order to obtain the desired compounds with a good regiocontrol. (C) 1998 Elsevier Sci ence Ltd. All rights reserved.