THE SYNTHESIS OF (+ -)-AMINOGLUTETHIMIDE VIA VICARIOUS NUCLEOPHILIC AROMATIC-SUBSTITUTION OF HYDROGEN/

Authors
BUSHELL SM CRUMP JP LAWRENCE NJ PINEAU G
Citation
Sm. Bushell et al., THE SYNTHESIS OF (+ -)-AMINOGLUTETHIMIDE VIA VICARIOUS NUCLEOPHILIC AROMATIC-SUBSTITUTION OF HYDROGEN/, Tetrahedron, 54(10), 1998, pp. 2269-2274
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
10
Year of publication
1998
Pages
2269 - 2274
Database
ISI
SICI code
0040-4020(1998)54:10<2269:TSO(-V>2.0.ZU;2-W
Abstract
The synthesis of aminoglutethimide via a one-pot coupling of nitrobenz ene, ethyl 2-chlorobutyrate and 3-bromopropionitrile has been achieved via a process involving sequential vicarious nucleophilic aromatic su bstitution and alkylation. (C) 1998 Elsevier Science Ltd. All rights r eserved.