Sm. Bushell et al., THE SYNTHESIS OF (+ -)-AMINOGLUTETHIMIDE VIA VICARIOUS NUCLEOPHILIC AROMATIC-SUBSTITUTION OF HYDROGEN/, Tetrahedron, 54(10), 1998, pp. 2269-2274
The synthesis of aminoglutethimide via a one-pot coupling of nitrobenz
ene, ethyl 2-chlorobutyrate and 3-bromopropionitrile has been achieved
via a process involving sequential vicarious nucleophilic aromatic su
bstitution and alkylation. (C) 1998 Elsevier Science Ltd. All rights r
eserved.