A SIMPLE AND EFFICIENT STRATEGY FOR THE PREPARATION OF 5-PHOSPHORYLATED IMIDAZOL-2-ONES FROM PRIMARY BETA-ENAMINOPHOSPHONATES

Authors
PALACIOS F DERETANA AMO OYARZABAL J EZPELETA JM
Citation
F. Palacios et al., A SIMPLE AND EFFICIENT STRATEGY FOR THE PREPARATION OF 5-PHOSPHORYLATED IMIDAZOL-2-ONES FROM PRIMARY BETA-ENAMINOPHOSPHONATES, Tetrahedron, 54(10), 1998, pp. 2281-2288
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
10
Year of publication
1998
Pages
2281 - 2288
Database
ISI
SICI code
0040-4020(1998)54:10<2281:ASAESF>2.0.ZU;2-4
Abstract
An easy and efficient synthesis of imidazol-2-ones 5 substituted with a phosphonate group in the 5-position is described. The key step is a heterocyclization of functionalized enamines 3. These compounds 3 are formed by addition of primary beta-enaminophosphonates 1 to diethyl'az odicarboxylate 2. (C) 1998 Elsevier Science Ltd. All rights reserved.