SYNTHESIS OF A NEW PHOSPHOLIPASE A(2) INHIBITOR OF AN ALDEHYDE TERPENOID AND ITS POSSIBLE INHIBITORY MECHANISM

Authors
TANAKA K KAMATANI M MORI H FUJII S IKEDA K HISADA M ITAGAKI Y KATSUMURA S
Citation
K. Tanaka et al., SYNTHESIS OF A NEW PHOSPHOLIPASE A(2) INHIBITOR OF AN ALDEHYDE TERPENOID AND ITS POSSIBLE INHIBITORY MECHANISM, Tetrahedron letters, 39(10), 1998, pp. 1185-1188
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
10
Year of publication
1998
Pages
1185 - 1188
Database
ISI
SICI code
0040-4039(1998)39:10<1185:SOANPA>2.0.ZU;2-F
Abstract
3-(E)-Methoxycarbonyl-2,4,6-trienal compound A was stereoselectively s ynthesized and found to show strong inhibitory activity toward phospho lipase A(2) (PLA(2)) from bovine pancreas. As the inhibitory mechanism of PLA(2) by A, the irreversible formation of dihydropyridine resulti ng from the reaction of A with lysine residues in PLA(2) is proposed b ased on the model reactions. (C) 1998 Elsevier Science Ltd. All rights reserved.