FIRST ENANTIOSELECTIVE ADDITION OF DIALKYLZINC TO KETONES PROMOTED BYTITANIUM(IV) DERIVATIVES

Authors
RAMON DJ YUS M
Citation
Dj. Ramon et M. Yus, FIRST ENANTIOSELECTIVE ADDITION OF DIALKYLZINC TO KETONES PROMOTED BYTITANIUM(IV) DERIVATIVES, Tetrahedron letters, 39(10), 1998, pp. 1239-1242
Citations number
55
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
10
Year of publication
1998
Pages
1239 - 1242
Database
ISI
SICI code
0040-4039(1998)39:10<1239:FEAODT>2.0.ZU;2-K
Abstract
The reaction of dimethyl or diethylzinc with ketones in the presence o f a stoichiometric amount of titanium tetraisopropoxide and a catalyti c amount (20 mol %) of camphorsulfonamide derivatives as chiral ligand s leads to the formation of the corresponding enantioenriched alcohols with enantiomeric ratios up to 94.5:5.5, the best results being obtai ned when phenones are used as substrates independently of the zinc rea gent. (C) 1998 Elsevier Science Ltd. All rights reserved.