Malignant mesenchymal tumors of the larynx constitute 0.3% to 1% of al
l laryngeal cancers, and of these osteosarcoma is the rarest. Our revi
ew of the literature identified only 12 cases of osteosarcoma of the l
arynx, all of which occurred in men. Rarely, osteosarcoma of the laryn
x may follow radiation therapy for squamous cell carcinoma, or the lar
ynx may be the site of metastatic osteosarcoma, We report a case of pr
imary laryngeal osteosarcoma arising in the cricoid cartilage and the
first case of osteosarcoma of the larynx occurring in a woman.