P. Dumont et al., BRONCHOALVEOLAR CARCINOMA - HISTOPATHOLOGIC STUDY OF EVOLUTION IN A SERIES OF 105 SURGICALLY TREATED PATIENTS, Chest, 113(2), 1998, pp. 391-395
Citations number
14
Categorie Soggetti
Respiratory System","Cardiac & Cardiovascular System
Study objective: The clinical characteristics, histopathologic conditi
on, and outcome of bronchoalveolar carcinoma (BAC) were studied to det
ect possible prognostic indicators. Design: A retrospective review was
conducted of 97 patients who had a curative resection for BAC between
1975 and 1993. Patients: There were 83 men and 14 women with a mean a
ge of 59 years (30 to 75 years). Interventions: Resection comprised lo
bectomy in 84 cases (87%), bilobectomy, pneumonectomy, and a wedge exc
ision. Results: Sixty-two percent of patients were asymptomatic, The r
adiographic pattern was a solitary nodule in 85% of patients and lobar
pneumonitis or diffuse infiltrate in 15%, In 12% of patients, the sol
itary lesion had been stable for period of 2 to 7 years before diagnos
is, The TNM staging of the disease included 71 patients with stage I,
14 with stage II, and 12 with stage IIIA, Review of the gross patholog
ic features revealed web-circumscribed tumors in 88% of patients and d
iffuse or multifocal tumors in 12%. Mucinous differentiation was prese
nt in 43% of patients, vascular invasion in 22%, and aerogenous spread
in 49%. Overall survival was 89% at 1 year, 76% at 2 years, 48% at 5
years, and 39% at 10 years. The survival curves according to histologi
c features showed a statistically significant difference between diffu
se lesions and nodular lesions, between lesions with and without aerog
enous spread (diffuse lesions excluded), and between lesions with and
without vascular invasion. Conclusions: The natural history of BAC is
especially influenced by its nodular or diffuse nature, vascular invas
ion, and aerogenous spread.