E. Rodriguezdiaz et al., CUTANEOUS LYMPHADENOMA - AN ADNEXAL NEOPLASM WITH INTRALOBULAR ACTIVATED LYMPHOID-CELLS, The American journal of dermatopathology, 20(1), 1998, pp. 74-78
Cutaneous lymphadenoma is an uncommon epithelial neoplasm with a contr
overted adnexal differentiation. We report a typical case of cutaneous
lymphadenoma that developed on the left cheek of a 18-year-old woman.
Histologically, the neoplasm consisted of lobules of basaloid cells w
ith a peripheral palisading array and filled with a lymphocyte-predmon
inant mixed cellular population. Numerous intralobular cells with ampl
e amphopilic cytoplasm, large vesicular nuclei, and prominent nucleoli
also were noticed. Immunohistochemical study showed labeling of these
Reed-Sternberg-like large cells by antibodies against CD30 antigen. O
ur findings suggest that cutaneous lymphadenoma is a poorly differenti
ated adnexal neoplasm, probably trichoblastoma-related, where a singul
ar interaction with several immune cells is established, including act
ivated large lymphocytes analogous to those malignantly proliferating
in Hodgkin's disease.