CUTANEOUS LYMPHADENOMA - AN ADNEXAL NEOPLASM WITH INTRALOBULAR ACTIVATED LYMPHOID-CELLS

Cutaneous lymphadenoma is an uncommon epithelial neoplasm with a contr overted adnexal differentiation. We report a typical case of cutaneous lymphadenoma that developed on the left cheek of a 18-year-old woman. Histologically, the neoplasm consisted of lobules of basaloid cells w ith a peripheral palisading array and filled with a lymphocyte-predmon inant mixed cellular population. Numerous intralobular cells with ampl e amphopilic cytoplasm, large vesicular nuclei, and prominent nucleoli also were noticed. Immunohistochemical study showed labeling of these Reed-Sternberg-like large cells by antibodies against CD30 antigen. O ur findings suggest that cutaneous lymphadenoma is a poorly differenti ated adnexal neoplasm, probably trichoblastoma-related, where a singul ar interaction with several immune cells is established, including act ivated large lymphocytes analogous to those malignantly proliferating in Hodgkin's disease.