HB SILVER-SPRINGS [BETA-131(H9)GLN-]HIS], A NEW HEMOGLOBIN-VARIANT FOUND IN 6 AFRICAN-AMERICANS

Authors
HOYER JD WICK MJ THIBODEAU SN KECHTEIGER KS COOK JD FAIRBANKS VF
Citation
Jd. Hoyer et al., HB SILVER-SPRINGS [BETA-131(H9)GLN-]HIS], A NEW HEMOGLOBIN-VARIANT FOUND IN 6 AFRICAN-AMERICANS, Hemoglobin, 22(1), 1998, pp. 37-44
Citations number
21
Categorie Soggetti
Biology,Hematology
Journal title
Hemoglobin → ACNP
ISSN journal
03630269
Volume
22
Issue
1
Year of publication
1998
Pages
37 - 44
Database
ISI
SICI code
0363-0269(1998)22:1<37:HS[ANH>2.0.ZU;2-H
Abstract
We report a new hemoglobin variant which we have named Hb Silver Sprin gs. This variant results from a substitution CAG-->CAC (Gln-->His) at codon 131 of the beta chain. It was detected only by cation exchange h igh performance liquid chromatography. This is the fifth reported subs titution at codon 131. This variant does not appear to have any clinic al or hematologic manifestations.