Infective endocarditis remains an important and life-threatening infec
tion despite improvements in diagnosis and management. There is curren
tly a greater role for nosocomial acquisition of organisms and immunos
uppression in the pathogenesis of this disease and emergence of a broa
der spectrum of infective organisms including those not commonly isola
ted from the mouth such as staphylococci. We report a case of infectiv
e endocarditis caused by Staphylococcus aureus in which the patient de
veloped disseminated intravascular coagulation and multiple septic inf
arcts resulting in a frontal robe brain abscess. Multiple dental extra
ctions were complicated by delayed postextraction hemorrhage and the i
mmediate cause of death was abdominal hemorrhage. The dental managemen
t in infective endocarditis should be planned in consultation with the
attending physician, and should take into account both the causative
organism and the presence of complications. When the oral cavity canno
t be proven as the bacterial source for infective endocarditis, the im
mediate dental management should be directed toward improving the pati
ent's oral hygiene and providing pain relief. Definitive long-term tre
atment, including any extractions, is ideally delayed until the patien
t has fully recovered from the infective endocarditis and its attendan
t complications.