ADENOSQUAMOUS CARCINOMA - A CASE-REPORT WITH IMMUNOHISTOCHEMICAL EVALUATION

The histogenetic origin of adenosquamous carcinoma, a high-grade varia nt of malignant epithelial neoplasm, has long been debated. We report a case that clearly demonstrated a mucosal surface epithelial origin. This concept was supported through histologic analysis of hematoxylin- and eosin-stained sections, as well as by the pattern of immunohistoch emical reactivity with antibodies directed against low and high molecu lar weight cytokeratins, cell adhesion molecules (CAM 5.2), and carcin oembryonic antigens. The histologic differential diagnosis, biological behavior, and prognosis of adenosquamous carcinoma are also examined.