HYPOTENSIVE EFFECT OF GAMMA-GLUTAMYLMETHYLAMIDE IN SPONTANEOUSLY HYPERTENSIVE RATS

Authors
YOKOGOSHI H KOBAYASHI M
Citation
H. Yokogoshi et M. Kobayashi, HYPOTENSIVE EFFECT OF GAMMA-GLUTAMYLMETHYLAMIDE IN SPONTANEOUSLY HYPERTENSIVE RATS, Life sciences, 62(12), 1998, pp. 1065-1068
Citations number
12
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
62
Issue
12
Year of publication
1998
Pages
1065 - 1068
Database
ISI
SICI code
0024-3205(1998)62:12<1065:HEOGIS>2.0.ZU;2-J
Abstract
The effect of gamma-glutamylmethylamide(GMA), one of the components of green tea extract, on the blood pressure in spontaneously hypertensiv e rats (SHR) was investigated. The effect of glutamic acid and r-gluta mylethylamide (theanine), which is structually similar to GMA, was als o examined. When SHR were injected with glutamic acid (2000mg/kg), the blood pressure was not altered. The same dose of theanine decreased i t significantly. GMA administration to SHR reduced the blood pressure significantly, and its degree of hypotensive action was more effective than that by theanine administration.