The role of completion thyroidectomy after lobectomy for well-differen
tiated thyroid carcinoma remains controversial. The purpose of the pre
sent study is to compare the relative safety of a one-stage versus a t
wo-stage approach in the management of thyroid cancer. Thirty consecut
ive patients with thyroid carcinoma were studied. In 14 patients, froz
en-section diagnosis of carcinoma allowed total thyroidectomy at the i
nitial operation. In 16 patients, carcinoma was found only on permanen
t section; thus, completion thyroidectomy was undertaken as a second s
tage. Transient hypocalcemia occurred in one patient in each group (on
e-stage, 7%; two-stage, 6%). There was one unilateral recurrent nerve
paresis in the one-stage group and none in the two-stage group. We con
clude that a two-stage procedure is a safe and effective approach for
the treatment of thyroid cancer and can be employed in those instances
in which the diagnosis of malignancy is insecure at the initial opera
tion.