Objective: To determine whether laser-cured fibrinogen glue can close
bleb leaks in rabbits. Methods: Full-thickness filtration surgery with
intraoperative mitomycin and a sutured limbus-based conjunctival flap
was performed in 1 eye each of 19 New Zealand albino rabbits. On the
second postoperative day, a 2- to 3-mm hole was made in the bleb. In 9
rabbits, the hole was glued using fibrinogen glue with indocyanine gr
een dye added. The glue was ''cured'' with a diode laser. Eyes that ha
d been glued and developed a subsequent leak had the glue reapplied on
the day the leak was detected. Results: The glue remained on the conj
unctiva for an average (mean+/-SD) of 1.9+/-1.8 days (range, 0-5 days)
. The last day of bleb leak for the rabbits with glued eyes was 1.6+/-
2.4 days; for the control rabbits, it was 8.0+/-4.4 days (P=.001, Mann
-Whitney U test). Conclusion: Laser-cured fibrinogen glue is effective
in closing bleb leaks in rabbits.