CONTROLLED-RELEASE DOSAGE FORM OF IBUPROF EN WHICH WAS LAYERED BY TALC WITH ETHYLCELLULOSE BINDER

We studied the controlled release dosage form of ibuprofen which was l ayered by talc with an ethylcellulose (EC) binder. In this dosage form , the amount of EC was variable in the range of 4.1-6.0 g according to the operating conditions (e.g. slit air temperature), However the rel ease rate of ibuprofen was changed according to these conditions, It w as, therefore, difficult to assure the reproducible productivity of su stained-release granules of ibuprofen. We designed formulations of EC binder solutions; EC-ethanol, EC-ethanol-water and EC-ethanol-water-hy droxypropylmethylcellulose (HPMC), and investigated the release rate o f ibuprofen which was prepared by each formulation. The results showed that the release rate of ibuprofen was not changed in the range of 4. 2-10.3 g of the amount of EC used in the EC-ethanol-water HPMC formula tion.